Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders.

In 30 seconds

This meta-analysis examined resting-state functional MRI studies to identify regional homogeneity (ReHo) alterations in major depressive disorder (MDD), bipolar disorder (BD), and schizophrenia (SZ). Analyzing 90 studies with 3764 patients and 3590 healthy controls, the study found a common ReHo increase in the right inferior frontal gyrus, alongside disorder-specific alterations across various brain networks.

Key findings

• Common ReHo increase identified in the right inferior frontal gyrus across disorders.
• MDD-specific abnormalities primarily involved the default mode and subcortical networks.
• BD-specific alterations were mostly located within the default mode network.
• SZ exhibited widespread dysfunction across frontoparietal and somatomotor networks.

Why it matters

Understanding the shared and distinct neurofunctional patterns in affective and psychotic disorders can enhance precision diagnostics and inform targeted therapeutic strategies, ultimately improving patient outcomes in psychiatry.