PRAME Immunostaining in Acral Melanocytic Proliferations: A Meta-Analysis.
Am J DermatopatholMay 12, 2026 (epub)
Clinical ResearchDermatology
Ana L Toussaint, Carlos Sánchez-Cárdenas, Ruth Fuentes-García et al.
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In 30 seconds
This meta-analysis evaluated the diagnostic utility of PRAME immunohistochemistry in acral melanocytic proliferations, analyzing 930 lesions from 13 studies. The findings indicated that PRAME expression in acral melanoma achieved a diagnostic accuracy with a sensitivity of 78% and specificity of 92% at a cutoff of 3+/50%.
Key findings
- PRAME expression in acral melanoma demonstrated a sensitivity of 78% and specificity of 92%.
- The analysis included 930 lesions, comprising 557 malignant and 373 benign cases.
- The study utilized a random-effects model to assess diagnostic accuracy.
Why it matters
Understanding the diagnostic accuracy of PRAME immunostaining can aid clinicians in distinguishing between malignant and benign acral melanocytic lesions, which is crucial given the aggressive nature of acral melanoma.