Desmoplastic Trichilemmoma Mimicking Basal Cell Carcinoma: Two New Cases, Systematic Review of 92 Cases and Dual Staining Diagnostic Approach.

Am J DermatopatholMay 20, 2026 (epub)
Case ReportDermatology

Mokhtar H Abdelhammed, Hong Yu, Nisha S Ramani

✦ AI-curated · Sources linked

Case in brief

Two cases of desmoplastic trichilemmoma (DTM) were presented, both mimicking basal cell carcinoma (BCC) due to overlapping features. Histopathological examination revealed a lobular growth pattern and desmoplastic stroma. Immunohistochemical analysis showed CD34 positivity and BerEP4 negativity, aiding in the differentiation from BCC. The cases highlight the importance of accurate diagnosis to ensure appropriate management.

Diagnostic / clinical pearl

Clinicians should utilize the CD34-BerEP4 dual-marker approach for accurate differentiation between desmoplastic trichilemmoma and basal cell carcinoma, as misdiagnosis can lead to inappropriate treatment.

Source

PubMed · PMID 42358005

Published in Am J Dermatopathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

ShareTelegramLinkedIn

AI-generated summaries may contain errors or omissions. Verify clinically important information with the original publication.

More in Dermatology

Clinical ResearchHematology

Ponatinib-Blinatumomab or Imatinib-Chemotherapy for Adult Ph-Positive ALL.

This multicenter, phase 3 randomized trial compared frontline ponatinib plus blinatumomab with imatinib plus chemotherapy in adults with Philadelphia-positive acute lymphoblastic leukemia.

N Engl J MedOct 15, 2026Read summary
Clinical ResearchHematology

Efficacy and safety of mitapivat in patients with sickle cell disease (RISE UP): a phase 3, double-blind, global, randomised, placebo-controlled trial.

RISE UP was a phase 3, double-blind, global, randomised, placebo-controlled trial conducted at 69 sites in 15 countries. It evaluated twice-daily mitapivat in patients older than 16 years with sickle cell disease…

LancetOct 24, 2026Read summary
Clinical ResearchRheumatology

Ianalumab for the Treatment of Patients with Sjögren's Disease.

Two 52-week, double-blind, randomized, placebo-controlled phase III trials evaluated monthly or less frequent ianalumab in patients with active Sjögren's disease.

N Engl J MedOct 22, 2026Read summary

Want this personalized?

Stop searching the literature. Choose what you follow and xxcode will build your personalized medical digest.

  • Your specialties
  • Your filters and thresholds
  • Clinical Research + Case Reports, tuned separately
  • Automatic weekly delivery
  • Audio and text
Create my personalized digestSee plans

Prefer listening? Personalized audio digests are available with Pro.

Stay updated for free

Get the 3 most interesting publications in one specialty each week.

Weekly email. Unsubscribe anytime.