Nonfamilial Unilateral Linear Eccrine Syringofibroadenoma of the Plantar Surface: A Diagnostic Consideration in Acral Eccrine Proliferations.
Jing Xu, Lianjun Chen, Huyan Chen et al.
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Case in brief
A middle-aged woman presented with a long-standing unilateral linear lesion on the plantar surface of her foot. Histopathological analysis revealed anastomosing epithelial cords and eccrine duct-like structures within a fibrovascular stroma, confirming the diagnosis of eccrine syringofibroadenoma (ESFA). The lesion was successfully identified and differentiated from other similar conditions.
What made this case unusual
The case highlights the nonfamilial unilateral linear subtype of ESFA, which is exceedingly rare and can complicate diagnosis, especially in acral locations.
Diagnostic / clinical pearl
Clinicians should be aware of the distinctive histopathological features of eccrine syringofibroadenoma to differentiate it from other eccrine proliferations.
Why it matters
This case underscores the importance of recognizing rare benign neoplasms like ESFA in dermatopathology, particularly in challenging acral presentations.