Verrucous Variant of Bowen Disease.

Am J DermatopatholApr 10, 2026 (epub)
Case ReportDermatology

Zita Álvarez Bobillo, Angel Fernandez-Flores

✦ AI-curated · Sources linked

Case in brief

A 91-year-old woman had a long-standing, 25 mm yellowish verrucous lesion on her left leg that clinically suggested verrucous carcinoma. Excision showed an exophytic verrucous tumor without dermal invasion. Histology demonstrated full-thickness architectural disarray, cytological atypia, and pagetoid spread. Immunohistochemistry showed strong, diffuse p16 and Ki67 positivity throughout the epidermis, with negative p53 staining. These findings established verrucous Bowen disease, a squamous cell carcinoma in situ variant.

What made this case unusual

The lesion’s verrucous appearance mimicked verrucous carcinoma, but histology showed an in situ tumor without dermal invasion; diffuse p16 positivity supported verrucous Bowen disease.

Diagnostic / clinical pearl

For an exophytic, hyperkeratotic lesion resembling verrucous carcinoma, assess for full-thickness atypia and dermal invasion; diffuse p16 staining can support verrucous Bowen disease.

Source

PubMed · PMID 42358038

Published in Am J Dermatopathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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