The clinical net benefit of venous thromboembolism prophylaxis in mild-risk thrombophilia and pregnancy: a systematic review and meta-analysis.
Am J Obstet Gynecol MFMJun 26, 2026 (epub)
Katherine Klein, Shane E Wing, Lily Chen et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the effectiveness of thromboprophylaxis in preventing venous thromboembolism (VTE) in 1320 pregnant women with mild-risk inherited thrombophilia. The study found that thromboprophylaxis was associated with a significantly lower risk of VTE, with rates of 0.8% in the thromboprophylaxis group compared to 4.4% in the no thromboprophylaxis group (OR 0.20, 95% CI 0.08-0.50).
Key findings
- Thromboprophylaxis reduced VTE risk to 0.8% compared to 4.4% without it.
- The odds ratio for VTE with thromboprophylaxis was 0.20 (95% CI 0.08-0.50).
- Five studies were included in the meta-analysis, encompassing 1320 women.
- Secondary outcomes could not be analyzed due to low incidence.
Why it matters
Understanding the benefits of thromboprophylaxis in pregnant women with mild-risk thrombophilia is crucial for preventing VTE, a serious complication that can affect maternal and fetal health.