Targeting cortico-striatal-amygdalar networks via theta-band frontoparietal synchronization in opioid use disorder: a randomized tACS-fMRI Trial.
Mol PsychiatryJun 26, 2026 (epub)
Ghazaleh Soleimani, Rayus Kuplicki, Martin P Paulus et al.
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In 30 seconds
This randomized controlled trial investigated the effects of theta-band transcranial alternating current stimulation (tACS) on brain activity and craving in 60 males with opioid use disorder (OUD). The active tACS group showed decreased opioid cue-related brain activity compared to the sham group, particularly in reward processing areas, indicating potential for network-targeted neuromodulation in addiction treatment.
Key findings
- Active tACS significantly reduced post-stimulation opioid cue-related activity compared to sham.
- Increased right frontoparietal network engagement was observed after active stimulation (β = 2.63, p= 0.0308).
- Top-down inhibitory regulation of the frontoparietal network on the ventral striatum and amygdala increased following stimulation.
- Electric field strength predicted frontoparietal network engagement in the active group (r = 0.43, p= 0.02).
Why it matters
The study highlights the potential of theta-band tACS to modulate brain activity associated with opioid cues, suggesting a novel approach for enhancing treatment strategies in opioid use disorder through targeted neuromodulation.