Subcapsular versus total orchiectomy in advanced prostate cancer: A systematic review and meta-analysis of clinical and patient-reported outcomes.
Angga D M Pratama, Steven A Shenelo, Rizqi A F Kamila et al.
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In 30 seconds
This systematic review and meta-analysis evaluated clinical and patient-reported outcomes of subcapsular versus total orchiectomy in 759 men with advanced prostate cancer. The study found that subcapsular orchiectomy resulted in higher postoperative testosterone levels (mean difference = 4.03) and greater treatment satisfaction (odds ratio = 3.78) compared to total orchiectomy, despite similar quality of life outcomes.
Key findings
- Subcapsular orchiectomy led to higher postoperative testosterone levels (mean difference = 4.03).
- Patients undergoing subcapsular orchiectomy reported greater treatment satisfaction (odds ratio = 3.78).
- No significant differences were observed in overall functional assessment scores between the two procedures.
Why it matters
Understanding the trade-offs between hormonal suppression and patient satisfaction is crucial for clinicians when discussing surgical options for advanced prostate cancer, as it can influence treatment decisions and patient quality of life.