Any impact of pre-operative radiotherapy on renal function in retroperitoneal soft tissue sarcomas? A secondary ancillary analysis of the EORTC 62092 STRASS 1 trial.
Radiother OncolJun 27, 2026 (epub)
Cecile Le Pechoux, Claudia Sangalli, Felix Boakye Oppong et al.
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In 30 seconds
This ancillary analysis of the EORTC 62092 STRASS 1 trial evaluated the impact of preoperative radiotherapy on renal function in patients with retroperitoneal soft tissue sarcomas. Among 181 eligible patients, the study found no significant increase in renal complications associated with preoperative radiotherapy compared to surgery alone, with 88 (96.7%) and 82 (91.1%) experiencing RIFLE events, respectively.
Key findings
- 170 patients experienced RIFLE events, with 88 (96.7%) in the surgery alone arm and 82 (91.1%) in the preoperative RT arm.
- No significant association was found between radiotherapy dose parameters and the risk of RIFLE events.
- The study followed patients for an average of 80 months post-surgery.
Why it matters
Understanding the impact of preoperative radiotherapy on renal function is crucial for optimizing treatment strategies in patients with retroperitoneal sarcomas, particularly given the potential for kidney resection during surgery.