Meta-analysis of Short-term Clinical and Survival Outcomes of Full-left-full-right Split Liver Transplantation for 2 Recipients.
Shahin Hajibandeh, Shahab Hajibandeh, Farhan Ahmad et al.
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In 30 seconds
This meta-analysis evaluated the outcomes of full-left-full-right split liver transplantation (FLFR-SLT) for two recipients, comparing it to whole liver transplantation (WLT) and between full-right and full-left grafts. The analysis included 16 observational studies with 3139 patients. FLFR-SLT showed similar short-term outcomes for graft and patient survival compared to full-right and full-left grafts, but significantly increased complications and decreased survival when compared to WLT.
Key findings
- No significant difference in hepatic artery thrombosis between full-right and full-left grafts (OR 1.09; P = 0.88).
- FLFR-SLT significantly increased risk of venous complications (OR 32.8; P = 0.002) compared to WLT.
- 1-year graft survival was significantly lower for FLFR-SLT compared to WLT (OR 0.33, P < 0.00001).
- 1-year patient survival was significantly lower for FLFR-SLT compared to WLT (OR 0.46, P = 0.0003).
Why it matters
Understanding the comparative outcomes of FLFR-SLT and WLT is crucial for clinicians involved in liver transplantation, as it informs decision-making regarding graft selection and potential complications, ultimately impacting patient care and survival.