Enamel pits and enamel developmental defects in tuberous sclerosis complex: A descriptive synthesis and pooled prevalence analysis.
Med Oral Patol Oral Cir BucalSep 1, 2026 (epub)
H Nakagawa
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In 30 seconds
This systematic review analyzed enamel pits and developmental defects in patients with tuberous sclerosis complex (TSC), synthesizing data from seven studies involving 217 patients. The pooled prevalence of enamel pits was found to be 66%, indicating a significant occurrence of these defects in TSC, though with substantial heterogeneity in reporting methods.
Key findings
- The pooled prevalence of enamel pits in TSC was 66%, with substantial heterogeneity (I²=77%).
- Individual prevalence estimates ranged from 0% in deciduous dentition to 100% in studies using staining or SEM.
- Variability in findings was associated with dentition type, age, diagnostic criteria, and assessment methods.
Why it matters
Understanding the prevalence and characteristics of enamel defects in TSC is crucial for clinicians, as these subtle oral findings may aid in the diagnosis and management of the condition. Standardized assessment can improve recognition and care.