Vaspin-Cytokine Interactions in Chronic Low Back Pain: Links Between Obesity, Inflammation, and Traction Therapy Response.
J Interferon Cytokine ResJun 29, 2026 (epub)
Clinical ResearchPhysical Medicine & Rehabilitation
Marzena Ratajczak, Alexander Kalinkovich, Gregory Livshits
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In 30 seconds
This prospective clinical trial examined the effects of traction therapy on serum vaspin levels in women aged 34-50 with chronic low back pain (LBP), comparing those with obesity to those with normal BMI. The study found that after therapy, LBP intensity, Oswestry Disability Index (ODI), and Roland-Morris Disability Questionnaire (RMDQ) scores significantly decreased, while vaspin levels increased only in women with normal BMI.
Key findings
- Post-therapy, LBP intensity, ODI, and RMDQ scores significantly decreased in both groups.
- Vaspin concentration increased significantly only in women with normal BMI after traction therapy.
- Vaspin negatively correlated with ODI post-therapy, indicating a potential link to disability.
- IL-4 and IL-17A levels correlated with vaspin differently based on BMI status.
Why it matters
Understanding the relationship between vaspin levels and treatment response in chronic low back pain can help clinicians tailor interventions based on patient characteristics, such as BMI, potentially improving outcomes.