The Serum 25-Hydroxyvitamin D Response to Supplemental Vitamin D Is Temporarily Blunted with Elevated Circulating Cytokines at Baseline.
J Interferon Cytokine ResJun 29, 2026 (epub)
Clinical ResearchEndocrinology
Tyler Barker, Victoria E Rogers, Vanessa T Henriksen
✦ AI-curated · Sources linked
In 30 seconds
This randomized controlled trial investigated the impact of elevated baseline serum cytokines, particularly IL-6, on the serum 25-hydroxyvitamin D (25(OH)D) response to vitamin D supplementation in healthy adults and individuals with knee osteoarthritis. The study found that the increase in serum 25(OH)D at 7 days was significantly lower in those with elevated IL-6 compared to those with non-elevated IL-6 (P < 0.05).
Key findings
- The increase in serum 25(OH)D from baseline to 7 days was significantly lower in the elevated IL-6 group (P < 0.05).
- Serum IL-6 and other cytokines were significantly higher in the elevated IL-6 group at baseline (all P < 0.05).
- The 28-day change in serum 25(OH)D was inversely associated with baseline serum 25(OH)D (β = -0.57, P = 0.01).
- The 7-day change in serum 25(OH)D showed modest inverse associations with baseline serum IL-6 (β = -0.43, P < 0.01).
Why it matters
Understanding the interaction between cytokine levels and vitamin D metabolism is crucial for optimizing vitamin D supplementation strategies, particularly in populations with chronic inflammation, such as those with osteoarthritis.