Intralesional human papillomavirus vaccination for cutaneous verrucae: a systematic review and meta-analysis of therapeutic efficacy.
Charussri Leeyaphan, Sumanas Bunyaratavej, Pattriya Jirawattanadon et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the efficacy of intralesional human papillomavirus (HPV) vaccination for treating cutaneous warts in patients with chronic or persistent lesions. The analysis included six studies and found that HPV vaccination resulted in a significantly higher rate of complete wart clearance compared to intralesional normal saline, with a risk ratio of 18.54 (95% CI 6.59-52.18).
Key findings
- Intralesional HPV vaccination led to a complete clearance rate with a risk ratio of 18.54 compared to normal saline.
- Subgroup analyses showed comparable efficacy between bivalent and quadrivalent HPV vaccines.
- Adverse events reported were mild and localized.
Why it matters
The findings suggest that intralesional HPV vaccination could be an effective treatment option for patients with persistent or treatment-refractory cutaneous warts, potentially improving patient outcomes in dermatological practice.