Acute neuromuscular and metabolic responses to a novel low-load combined isometric and isotonic resistance training protocol.

Eur J Appl PhysiolJun 29, 2026 (epub)
Clinical ResearchPhysical Medicine & RehabilitationOpen access

Tomonari Sugano, Tomomi Nomura, Yukari Yoshie et al.

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In 30 seconds

This randomized controlled trial examined the acute physiological responses to a novel combined resistance training (CB) protocol in 48 healthy men. The CB protocol, which involved low-load isometric and isotonic contractions, produced significantly higher EMG amplitudes compared to low-intensity slow training (LST) and high-load (HL) training. Notably, the CB group showed a significant reduction in tissue oxygen saturation compared to HL.

Key findings

  • CB protocol elicited mean EMG amplitudes significantly greater than LST during the final set (p = 0.009, g = 1.23).
  • NIRS analysis showed a significantly lower change in tissue oxygen saturation in the CB group compared to HL (p = 0.001; g = 1.19).
  • Third-set integrated EMG was significantly higher in CB than in both HL (p = 0.002, g = 1.13) and LST (p < 0.001, g = 1.63).
  • Serum IGF-1 concentrations exhibited a significant post-exercise elevation across all groups (p < 0.001).

Why it matters

The findings suggest that the combined resistance training protocol can effectively stimulate neuromuscular and metabolic responses with lower mechanical stress, making it suitable for populations requiring joint-friendly exercise options.

Source

Published in Eur J Appl Physiol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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