Clinical Features, Treatment, and Outcomes for Oropharyngeal Adenoid Cystic Carcinoma: A Systematic Review.
Otolaryngol Head Neck SurgJun 29, 2026 (epub)
Gabriel A Hernandez-Herrera, Katelyn S Rourk, Lazaro R Peraza et al.
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In 30 seconds
This systematic review analyzed 44 studies involving 195 patients with oropharyngeal adenoid cystic carcinoma to describe clinical features, treatments, and outcomes. The findings indicated that 22.3% of patients had positive lymph nodes at diagnosis, and long-term survival rates showed 3-year overall survival between 71.5% to 100%.
Key findings
- The female-to-male ratio was 1.7:1 among patients.
- 22.3% of patients had positive lymph nodes at diagnosis.
- 3-year overall survival rates ranged from 71.5% to 100%.
- 36% of patients with disease progression developed distant metastases, primarily to the lungs.
Why it matters
Understanding the clinical features and outcomes of oropharyngeal adenoid cystic carcinoma can aid clinicians in early diagnosis and treatment planning, potentially improving patient management and survival rates.