Therapeutic approaches for functional Globus Pharyngeus: A systematic review of studies from 2000 to 2025.

In 30 seconds

This systematic review evaluated therapeutic interventions for functional globus pharyngeus in adults, analyzing 15 studies including eight randomized controlled trials. The review found that SSRIs and low-dose tricyclic antidepressants were more effective than acid-suppressive treatments. Psychological interventions also showed comparable benefits with fewer side effects.

Key findings

• SSRIs and low-dose tricyclic antidepressants outperformed acid-suppressive comparators in controlled trials.
• Psychological interventions provided similar benefits with fewer adverse effects.
• Transcutaneous electroacupuncture and auricular vagus nerve stimulation showed short-term improvement in small studies.
• Reassurance and clinical attention yielded symptom reduction comparable to active interventions.

Why it matters

Understanding effective treatments for functional globus pharyngeus is crucial for clinicians, as it can enhance patient management and improve quality of life. The findings support a biopsychosocial approach to treatment.