Clinical features, imaging findings, and treatment outcomes of optic neuritis associated with anti-CRMP5 antibodies: a systematic review.
J NeuroimmunolJun 27, 2026 (epub)
Rafael Martins Themoteo, Yang Han Yu, Joana Laura Aihara Barbosa et al.
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In 30 seconds
This systematic review analyzed 32 patients with optic neuritis associated with anti-CRMP5 antibodies. The study found that 87.1% had bilateral optic neuritis, with 64% experiencing visual acuity worse than 20/200. A significant 90.6% had an associated malignancy, primarily small-cell lung carcinoma. Overall mortality was 32.1% at a median follow-up of 9.5 months.
Key findings
- 87.1% of patients had clinically symptomatic bilateral optic neuritis.
- Overall mortality was 32.1% at a median follow-up of 9.5 months.
- 90.6% of cases had an associated malignancy, mostly small-cell lung carcinoma.
- Absence of tumor response to treatment was linked to 88.9% mortality.
Why it matters
Understanding the clinical features and outcomes of optic neuritis related to anti-CRMP5 antibodies is crucial for timely diagnosis and management, especially given the high association with malignancies and significant mortality rates.