Effects of different intensities of aerobic exercise on intestinal permeability and inflammatory response in older adults: Randomized clinical trial.
Patricia Cristina Da Silva Menegotte, Clodoaldo Antônio De Sá, Aline Mânica et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized clinical trial examined the effects of high-intensity versus low-intensity aerobic exercise on intestinal permeability and inflammatory responses in 29 older adults (≥60 years). The study found that high-intensity exercise significantly increased serum zonulin levels by 21.98 ng/mL compared to low-intensity exercise (p = 0.017), indicating a differential impact on intestinal barrier function.
Key findings
- High-intensity exercise increased serum zonulin by 21.98 ng/mL compared to low-intensity exercise (p = 0.017).
- No significant changes in inflammatory cytokines were observed after FDR correction (all q ≥ 0.066).
- IFN-γ showed a greater proportional reduction after high-intensity exercise, but was not significant after adjustments (q = 0.066).
Why it matters
Understanding the impact of exercise intensity on intestinal permeability and inflammation is crucial for developing effective interventions to mitigate age-related decline in older adults. This study highlights the need for tailored exercise prescriptions to optimize health outcomes.