From premature adrenarche to adult metabolic risk and hyperandrogenism: a systematic review and meta-analysis.
Thais Milioni Luciano, Mariana Peduti Halah, Luís Eduardo Cruvinel Pinto et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the long-term metabolic and reproductive outcomes of idiopathic premature adrenarche (IPA) in premenarcheal adolescent and adult women. The analysis included 21 studies with 635 females with IPA and 307 controls. Results indicated that women with IPA had a significantly higher BMI (mean difference: 1.4; CI: 1.0-1.9) and markers of insulin resistance compared to controls.
Key findings
- Women with IPA had a mean BMI increase of 1.4 compared to controls (CI: 1.0-1.9).
- IPA individuals exhibited elevated fasting insulin and insulin resistance markers.
- Hyperandrogenism markers, including Ferriman-Gallwey score and dehydroepiandrosterone sulfate, were significantly higher in IPA women.
- Secondary analyses showed higher triglycerides and lower high-density lipoprotein in the IPA group.
Why it matters
Understanding the long-term risks associated with IPA is crucial for clinicians, as it highlights the need for monitoring metabolic and reproductive health in affected women to prevent future complications.
What to keep in mind
GRADE assessment rated most outcomes as low certainty.