Optimizing mitomycin C in photorefractive keratectomy: A paired-eye comparison of 15- versus 30-second applications.
Mohamed Gaber Okasha, Abdallah Brakat, Amr Mounir et al.
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In 30 seconds
This prospective randomized paired-eye study compared 15- versus 30-second applications of 0.02% mitomycin C during wavefront-optimized photorefractive keratectomy in 50 patients with bilateral moderate myopia. Corneal haze was minimal and transient, with median scores of 0 at all visits after the first postoperative week. Haze scores declined over time in both groups, with no statistically significant between-group differences at any follow-up (P ≥ 0.08). At 6 months, median uncorrected distance visual acuity was 0.00 logMAR in both groups (P = 1.0).
Key findings
- Median corneal haze scores were 0 at all follow-up visits beyond 1 week in both application-duration groups.
- Haze severity decreased over time in both groups (P < 0.01), with no significant between-group differences at any visit (P ≥ 0.08).
- At 6 months, median uncorrected distance visual acuity was 0.00 logMAR in both groups (P = 1.0).
Why it matters
The paired-eye comparison suggests that, in this population and procedure, a 15-second application achieved haze and visual outcomes comparable to a 30-second application. This informs evaluation of mitomycin C exposure duration while keeping the evidence specific to moderate myopia treated with wavefront-optimized PRK and the follow-up reported.
What to keep in mind
The study included 50 patients and follow-up ended at 6 months; it does not establish longer-term outcomes or assess whether shorter exposure reduces cytotoxic risks.