18 F-MFBG Uptake From Multiple Focal "Hot Spots" to Superscan in a Pediatric Patient With High-risk Neuroblastoma.
Xiaoya Wang, Bingyan Zhang, Keyu Zhang et al.
✦ AI-curated · Sources linked
Case in brief
A 5-year-old girl with high-risk neuroblastoma presented for 18 F-MFBG PET/CT, which revealed multiple discrete focal 'hot spots.' Bone marrow aspiration confirmed metastatic involvement. Following 5 cycles of immunotherapy and chemotherapy, a follow-up PET/CT showed a significant change in biodistribution, transitioning from focal 'hot spots' to a superscan pattern, indicating disease progression.
What made this case unusual
The case illustrates the unique temporal evolution of 18 F-MFBG uptake from multiple discrete focal 'hot spots' to a superscan pattern, highlighting a shift in disease status.
Diagnostic / clinical pearl
Clinicians should be aware that changes in 18 F-MFBG uptake patterns can indicate disease progression in neuroblastoma, necessitating careful interpretation of PET/CT findings.
Why it matters
Understanding the evolution of imaging findings in neuroblastoma can aid in monitoring treatment response and disease progression, impacting clinical decision-making.