Ovarian reserve markers in World Health Organization type 1 anovulatory disorders: a systematic review and meta-analysis.
Sterre M H de Jong, Annelien C de Kat, Linda J Schoonmade et al.
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In 30 seconds
This systematic review and meta-analysis evaluated ovarian reserve markers, specifically anti-Müllerian hormone (AMH) and antral follicle count (AFC), in women with World Health Organization type 1 anovulation. Among 920 participants, the pooled standardized mean difference for AMH was 0.23 (95% CI -0.06 to 0.51), indicating variability in these markers compared to normo-ovulatory controls. The study highlights the challenges in interpreting ovarian reserve in this population.
Key findings
- The pooled standardized mean difference for AMH was 0.23 (95% CI -0.06 to 0.51).
- Ovarian reserve markers varied widely in women with WHO type 1 anovulation compared to normo-ovulatory controls.
- Longer anovulatory periods were associated with a decrease in AMH concentration and AFC.
- Low AMH and/or AFC may not accurately reflect true ovarian reserve in this population.
Why it matters
Understanding the limitations of ovarian reserve markers in women with WHO type 1 anovulation is crucial for accurate fertility assessments. Clinicians should be cautious in interpreting these markers, as prolonged hypothalamic suppression may lead to underestimation.