ENTF Neuromodulation Yields Reduced Disability After Stroke: An Individual Participant-Level Data Meta-Analysis.
StrokeJul 1, 2026 (epub)
Jeffrey L Saver, Joel Stein, Steven C Cramer et al.
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In 30 seconds
This meta-analysis pooled individual participant data from two randomized, sham-controlled trials to evaluate the efficacy of electromagnetic network-targeted field (ENTF) brain stimulation in reducing post-stroke disability. In a cohort of 124 patients, active ENTF treatment resulted in a significantly higher rate of freedom-from-disability at 8 to 12 weeks compared to sham (33.8% vs 11.9%; P = 0.005).
Key findings
- Active ENTF treatment led to 33.8% freedom-from-disability compared to 11.9% for sham (P = 0.005).
- Ordinal shift in disability strata favored ENTF with a P-value of 0.009.
- No serious adverse events were reported related to the device or procedure.
Why it matters
The findings suggest that ENTF may significantly enhance recovery and reduce disability in patients with subacute ischemic stroke, providing a potential new therapeutic option in stroke rehabilitation.