Ketone Bodies Derived From Medium-Chain Triglycerides Support Brain Metabolism and Function Under Hypoglycemia in Type 1 Diabetes Mellitus.
Domenico Tricò, Lihong Jiang, Daniel Spicer et al.
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In 30 seconds
This randomized controlled trial investigated the effects of medium-chain triglycerides (MCTs) on brain metabolism during hypoglycemia in individuals with type 1 diabetes mellitus (T1DM). The study found that MCT supplementation led to improved working memory performance and increased regional brain activation during clamped hypoglycemia compared to a standard diet. Notably, the contribution of β-hydroxybutyrate (BHB) to brain metabolism was greater in T1DM participants than in healthy controls.
Key findings
- MCT supplementation improved working memory performance during hypoglycemia compared to a standard diet.
- Participants with T1DM showed greater BHB contribution to brain metabolism than healthy controls.
- Regional brain activation was enhanced in T1DM participants receiving MCTs during hypoglycemia.
- Counterregulatory hormone responses to hypoglycemia were unaffected by MCT supplementation.
Why it matters
Cognitive impairment from insulin-induced hypoglycemia is a significant concern in type 1 diabetes. This study suggests that dietary MCTs may offer a novel approach to mitigate cognitive deficits during hypoglycemic episodes, potentially improving patient outcomes.