Tumor control and cranial nerve outcomes after Gamma Knife radiosurgery for Glomus jugulare tumors: a systematic review, meta-analysis, and institutional failure pattern analysis.
J Clin NeurosciJul 1, 2026 (epub)
Sarthak Sinha, Neil D Almeida, Victor Goulenko et al.
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In 30 seconds
This systematic review and meta-analysis evaluated the outcomes of Gamma Knife radiosurgery (GKRS) for glomus jugulare tumors across 26 cohorts, involving 590 tumors. The study found a pooled radiographic tumor control rate of 91% and a new or worsened cranial nerve deficit rate of 11%. The analysis highlights GKRS as an effective treatment option with manageable toxicity.
Key findings
- Pooled radiographic tumor control after GKRS was 91% (95% CI, 88-94).
- Pooled radiographic shrinkage was 51% (95% CI, 43-59).
- New or worsened cranial nerve deficits occurred in 11% (95% CI, 8-14).
- Hearing worsening was reported in 16% (95% CI, 10-24) of evaluable patients.
Why it matters
The findings underscore the effectiveness of GKRS in achieving tumor control with a low incidence of cranial nerve deficits, which is crucial for patient quality of life. Understanding these outcomes can guide treatment decisions and patient counseling.