Case Report: Pancreatic Paraganglioma Mimicking a Well-Differentiated Neuroendocrine Tumor: The Importance of Cytokeratin Immunohistochemistry.

Diagn CytopatholJul 1, 2026 (epub)
Case ReportPathology (Anatomic & Clinical)Oncology (Medical)Open access

Tanner Storozuk, Marc Vecchio

✦ AI-curated · Sources linked

Case in brief

A 79-year-old woman presented with an incidental lesion in the pancreatic head, initially suspected to be a well-differentiated neuroendocrine tumor. Endoscopic ultrasound and cytopathologic evaluation revealed neoplastic cells with neuroendocrine characteristics. Immunohistochemical analysis showed the tumor cells were negative for cytokeratins and positive for GATA-3, confirming the diagnosis of pancreatic paraganglioma.

Diagnostic / clinical pearl

Cytokeratin immunohistochemistry is crucial in differentiating pancreatic paragangliomas from well-differentiated neuroendocrine tumors, as it can prevent misdiagnosis.

Source

PubMed · PMID 42387308Free full text on PubMed Central

Published in Diagn Cytopathol. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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