Bridging to low-dose corticosteroids after satralizumab discontinuation in unplanned pregnancy: Two cases of AQP4-positive NMOSD.

Mult Scler Relat DisordJun 27, 2026 (epub)
Case ReportNeurologyObstetrics & Gynecology

Shichun Li, Haiyan Yao, Ting Li et al.

✦ AI-curated · Sources linked

Case in brief

Two patients with AQP4-positive neuromyelitis optica spectrum disorder (NMOSD) experienced unplanned pregnancies while on satralizumab. Following confirmation of pregnancy, satralizumab was discontinued, and both patients were managed with low-dose corticosteroids throughout their pregnancies. No relapses occurred, and both delivered healthy full-term infants. Satralizumab was resumed postpartum without any relapses during follow-up.

Diagnostic / clinical pearl

In cases of unplanned pregnancy in NMOSD patients on satralizumab, transitioning to low-dose corticosteroids may maintain disease stability without fetal exposure to the medication.

Source

PubMed · PMID 42391798

Published in Mult Scler Relat Disord. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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