Effect of continuous energy restriction combined with probiotic supplementation on parameters related to homeostatic and hedonic systems of food intake in adult men living with obesity: Data from a randomized, parallel, double-blind, placebo-controlled clinical trial.
Glaice Aparecida Lucin, Camila Guazzelli Marques, Ana Carolina Oumatu Magalhães et al.
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In 30 seconds
This randomized, double-blind, placebo-controlled trial evaluated the effects of continuous energy restriction (CER) combined with probiotic supplementation on appetite-related hormones and eating behaviors in adult men with obesity. Over 12 weeks, CER significantly reduced fat mass and leptin levels while increasing ghrelin levels. However, no additional benefits from probiotics were observed.
Key findings
- Leptin levels decreased significantly (p < 0.001; η 2 p = 0.463) after 12 weeks of CER.
- Ghrelin levels increased over time (p = 0.045; η 2 p = 0.164) in both groups.
- Binge eating reduced significantly (p < 0.001; η 2 p = 0.413) during the study.
- Absolute fat mass declined significantly (p < 0.001; η 2 p = 0.718) with CER.
Why it matters
Understanding the impact of dietary interventions on appetite regulation and eating behaviors is crucial for developing effective weight management strategies. This study highlights the importance of CER in reducing fat mass and improving eating behaviors, which may aid in long-term weight maintenance.
What to keep in mind
The study was underpowered for detecting intervention effects on ghrelin and emotional eating, which may limit the findings' robustness.