Maternal and neonatal outcomes of intrahepatic cholestasis of pregnancy in twin pregnancies: a systematic review and meta-analysis.
Lvping Gu, Jie Shen
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In 30 seconds
This systematic review and meta-analysis evaluated maternal and neonatal outcomes in twin pregnancies affected by intrahepatic cholestasis of pregnancy (ICP). Seven retrospective cohort studies were analyzed, revealing that ICP significantly increases the risk of preterm birth, cesarean delivery, and gestational diabetes. Notably, preterm birth was significantly higher in ICP cases compared to those without.
Key findings
- ICP in twin pregnancies significantly increased the risk of preterm birth (<37 weeks).
- Mean gestational age was significantly reduced in pregnancies affected by ICP.
- ICP was associated with higher rates of cesarean delivery and gestational diabetes mellitus.
- No significant association was found between ICP and stillbirth or postpartum hemorrhage.
Why it matters
Understanding the implications of ICP in twin pregnancies is crucial for managing maternal and neonatal health. Clinicians should be aware of the increased risks associated with ICP to optimize care and monitoring during pregnancy.
What to keep in mind
The evidence is primarily based on crude data from a limited number of studies, leading to high inter-study heterogeneity.