GIP contributes to postprandial regulation of splanchnic blood supply in humans with type 2 diabetes: a randomised, single-blinded, placebo-controlled, crossover study.
DiabetologiaJul 2, 2026 (epub)
Rasmus S Rasmussen, Sophie W Nielsen, Lotte Alstrup et al.
✦ AI-curated · Sources linked
In 30 seconds
This randomized, single-blinded, placebo-controlled crossover study examined the role of endogenous glucose-dependent insulinotropic polypeptide (GIP) in postprandial splanchnic blood flow in ten individuals with type 2 diabetes. The study found that oral glucose increased blood flow in the arteria mesenterica superior by 57%, which was reduced by 15% during GIP receptor antagonist infusion (p=0.012).
Key findings
- Oral glucose increased mean blood flow in arteria mesenterica superior by 57%.
- GIP receptor antagonist infusion reduced blood flow by 15% compared to saline infusion.
- Insulin secretion and C-peptide levels were lower during GIP antagonist infusion.
- Oral water did not affect any outcomes.
Why it matters
Understanding the role of GIP in splanchnic blood flow regulation may provide insights into metabolic dysfunction in type 2 diabetes, potentially guiding future therapeutic strategies.