Differences in Circulating Inflammatory Markers in Older Adults With and Without Sarcopenia: A Systematic Review and Meta-Analysis.
Konstantinos Prokopidis, Collin J C Exmann, Jordi Morwani-Mangnani et al.
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In 30 seconds
This systematic review and meta-analysis examined inflammatory markers in older adults with and without sarcopenia. The analysis included 44 studies and found that individuals with sarcopenia had significantly higher levels of inflammatory markers, including CRP (SMD, 0.27) and TNF-α (SMD, 0.78), compared to those without sarcopenia.
Key findings
- Sarcopenia was associated with higher CRP levels (SMD, 0.27; P < .01).
- High-sensitivity CRP levels were significantly elevated in sarcopenic individuals (SMD, 0.40; P < .01).
- IL-6 levels were higher in those with sarcopenia (SMD, 0.34; P < .01).
- TNF-α levels showed a significant increase in sarcopenic adults (SMD, 0.78; P < .01).
Why it matters
Understanding the inflammatory profile associated with sarcopenia can help clinicians identify at-risk older adults and potentially guide interventions aimed at reducing inflammation and improving muscle health.
What to keep in mind
The overall quality of the included studies was considered low, and publication bias was noted for IL-6.