Effects of garlic supplementation on glycemic indices in adults: a GRADE-assessed systematic review and dose-response meta-analysis of randomized controlled trials.

In 30 seconds

This systematic review and meta-analysis evaluated the effects of garlic supplementation on glycemic indices in adults, analyzing 27 randomized controlled trials with 1,619 participants. The study found that garlic supplementation significantly reduced fasting blood glucose by 2.76 mg/dL and glycated hemoglobin by 0.53%.

Key findings

• Garlic supplementation reduced fasting blood glucose by 2.76 mg/dL.
• Glycated hemoglobin decreased by 0.53% with garlic supplementation.
• No significant effects were observed on insulin or HOMA-IR.
• Greater reductions in fasting blood glucose were noted at lower doses (≤0.5 g/day).

Why it matters

Improving glycemic control is crucial for managing diabetes and reducing complications. Garlic supplementation may offer a simple dietary intervention to help achieve modest improvements in fasting blood glucose and HbA1c levels.