Effects of nutritional interventions on biomarkers of cellular senescence in humans: A systematic review.
Ageing Res RevJul 4, 2026 (epub)
Yao Lin, Abdullah Altulea, Marco Demaria
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In 30 seconds
This systematic review evaluated the effects of nutritional interventions on biomarkers of cellular senescence in humans, analyzing 29 studies with 3811 participants. The findings indicate that calorie restriction consistently reduced inflammatory and secretory factors associated with the senescence-associated secretory phenotype (SASP), while classical markers of cell cycle arrest and telomere length showed variable results.
Key findings
- Calorie restriction led to recurrent reductions in SASP-related inflammatory factors.
- Classical markers of cell cycle arrest showed little change across studies.
- N-3 polyunsaturated fatty acids may modulate some inflammatory markers, but evidence is limited.
- Calorie restriction mimetics like metformin and rapamycin had context-dependent effects.
Why it matters
Understanding how nutritional interventions influence cellular senescence biomarkers can inform strategies to mitigate age-related diseases. This knowledge is crucial for developing effective dietary recommendations aimed at promoting healthy aging.