Primary Multi-focal Central Nervous System Lymphoma Masquerading as a High-grade Insular Glioma - A Rare Case Report.

Ann Afr MedJul 7, 2026 (epub)
Case ReportNeurosurgeryOncology (Medical)Pathology (Anatomic & Clinical)Radiology (Diagnostic)

Ashish Chugh, Dipti Patil, Sarang Gotecha

✦ AI-curated · Sources linked

Case in brief

A 70-year-old immunocompetent woman had a large heterogeneous brain lesion with mass effect involving the insular cortex and perisylvian region. MRI findings initially suggested a high-grade glioma, prompting surgical resection. Histopathology and immunohistochemistry instead established primary CNS high-grade B-cell lymphoma with double expression of BCL2 and BCL6. The report describes the lesion’s atypical location and imaging appearance as a diagnostic challenge; tissue examination resolved the discrepancy and enabled recognition of lymphoma.

What made this case unusual

The lymphoma involved the insular and perisylvian regions and mimicked a high-grade glioma on imaging, rather than presenting in the deep cerebral structures where PCNSL typically arises.

Diagnostic / clinical pearl

An imaging impression of high-grade glioma may be misleading in an atypical PCNSL presentation; tissue diagnosis can establish the correct diagnosis.

Source

PubMed · PMID 42411390

Published in Ann Afr Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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