18 F-FAPI-04 PET/CT Outperforms 18 F-FDG in Detecting Multiple Muscle and Subcutaneous Adipose Tissue Involvement of Marginal Zone Lymphoma.

Clin Nucl MedJul 7, 2026 (epub)
Case ReportHematologyOncology (Medical)Radiology (Diagnostic)

Lijuan Feng, Hao Wang, Wei Zhang

✦ AI-curated · Sources linked

Case in brief

A 63-year-old man presented with marginal zone lymphoma (MZL) involving multiple muscles and subcutaneous adipose tissue, a rare occurrence. Imaging with 18 F-FAPI-04 PET/CT revealed significantly higher radiotracer uptake and better detection of lesions compared to 18 F-FDG PET/CT. Notably, 18 F-FAPI-04 identified occult involvement in the right neck muscle that was not visible on 18 F-FDG PET/CT.

Diagnostic / clinical pearl

18 F-FAPI-04 PET/CT is superior to 18 F-FDG PET/CT in detecting marginal zone lymphoma with muscle and subcutaneous adipose tissue involvement, particularly for lesions with mild FDG avidity.

Source

PubMed · PMID 42411760

Published in Clin Nucl Med. This summary was written by xxcode from the publication's abstract and metadata. It is not peer reviewed and is not a substitute for the original article. For clinical decisions, review the original publication.

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