Residual disease after radiologically complete vacuum-assisted breast excision in patients with ductal carcinoma in situ: A systematic review and meta-analysis.
BreastJun 29, 2026 (epub)
Sang Yull Kang, Hyun Jo Youn
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In 30 seconds
This systematic review and meta-analysis evaluated the rates of residual disease and upstaging to invasive carcinoma following radiologically complete vacuum-assisted breast excision (VABE) in patients with ductal carcinoma in situ (DCIS). Analyzing data from 12 studies involving 5302 patients, the pooled residual disease rate was found to be 67.4%, while the upstaging rate was 16.4%.
Key findings
- Pooled residual disease rate after VABE was 67.4% (95% CI 63.9-70.8%).
- Pooled upstaging rate to invasive carcinoma was 16.4% (95% CI 12.8-20.4%).
- Suspicious axillary lymph nodes were associated with a 12.16 odds ratio for residual disease.
- Lesion size ≤10 mm and low or intermediate nuclear grade were protective factors.
Why it matters
Understanding the rates of residual disease and upstaging after VABE is crucial for informing surgical management and patient counseling in DCIS. These findings highlight the need for careful patient selection and consideration of surgical excision as a standard of care.