Effectiveness of comprehensive geriatric assessment with patient coaching on toxicity, premature treatment interruption, unplanned hospitalisations, and survival in older patients with solid tumours: Secondary endpoints of the G-oncoCOACH study.
Eleonore Ravoet, Cindy Kenis, Lien Peeters et al.
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In 30 seconds
This secondary analysis of the G-oncoCOACH study evaluated the impact of Comprehensive Geriatric Assessment (CGA) with patient coaching on toxicity, treatment interruptions, hospitalizations, and survival in older patients (≥70 years) with solid tumors. In a multicenter randomized controlled trial involving 212 patients, no significant differences were found in grade 3/4 toxicity (44.9% vs 40.0%), treatment interruptions (40.2% vs 37.1%), or unplanned hospitalizations (53.3% vs 45.7%). Median overall survival was 23.5 months in the control group and 18.8 months in the intervention group (p = 0.47).
Key findings
- Grade 3/4 toxicity occurred in 44.9% of the control group versus 40.0% in the intervention group (p = 0.47).
- Premature interruption of systemic therapy was 40.2% in the control group compared to 37.1% in the intervention group (p = 0.56).
- Unplanned hospitalizations were 53.3% in the control group and 45.7% in the intervention group (p = 0.27).
- Median overall survival was 23.5 months in the control group and 18.8 months in the intervention group (p = 0.47).
Why it matters
Understanding the effectiveness of CGA with patient coaching in older cancer patients is crucial, as it may inform strategies to mitigate treatment-related toxicity and improve patient management, particularly in frail populations at risk for adverse outcomes.