The interplay between circadian misalignment or sleep disturbances and cognition and brain function in individuals with different degrees of insulin resistance - a systematic review.
Helena Zander Wodschow, Christina van Elst, Konni Kass et al.
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In 30 seconds
This systematic review investigates the relationship between circadian misalignment, sleep disturbances, and cognitive function in individuals with varying degrees of insulin resistance. The review of 27 studies found that disrupted circadian rhythms and sleep disturbances were negatively associated with brain health, potentially affecting insulin sensitivity. However, the effects of sleep duration and quality were inconclusive.
Key findings
- Disrupted circadian rhythmicity and sleep disturbances were negatively associated with brain health.
- The impact of sleep duration and quality on cognition was inconclusive.
- Methodological heterogeneity and reliance on cross-sectional designs limited definitive conclusions.
Why it matters
Understanding the interplay between sleep disturbances and cognitive outcomes in insulin-resistant individuals is crucial, as it may inform strategies to mitigate cognitive decline and improve overall brain health.
What to keep in mind
Methodological heterogeneity and limited control for confounders restricted definitive conclusions.