Current evidence and emerging strategies in the management of cerebrovascular disease: a systematic review and narrative synthesis of contemporary literature.
NeuroscienceJul 9, 2026 (epub)
Morenike Olufunmilayo Akpo, Joshua Othuke Orogu, Great Iruoghene Edo et al.
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In 30 seconds
This systematic review synthesizes evidence on cerebrovascular disease management, focusing on diagnostic and pharmacological advances. It highlights strong support for thrombectomy in anterior large vessel occlusion and dual antiplatelet therapy for minor strokes, showing a 44% relative risk reduction. The review identifies significant gaps in neuroprotection and rehabilitation evidence.
Key findings
- Thrombectomy for anterior large vessel occlusion is strongly recommended (IA recommendation).
- Dual antiplatelet therapy for minor stroke shows a 44% relative risk reduction.
- Only 9% of rehabilitation evidence is derived from randomized controlled trials.
- 22% of studies included in the review are from low- and middle-income countries.
Why it matters
Understanding the current landscape of cerebrovascular disease management is crucial for clinicians to navigate treatment options and address existing gaps in care, particularly in neuroprotection and rehabilitation strategies.