Environmental Toxicants and Polycystic Ovary Syndrome: Implications for a Metabolic-Ovarian Framework (PMOS) - A Systematic Review.
James O Ibibama, Polycarp Dauda Madaki, Kenechi Adachi Aliche et al.
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In 30 seconds
This systematic review evaluated the association between exposure to potentially toxic elements and endocrine disruptors in women with polycystic ovary syndrome (PCOS). Fourteen high-quality studies indicated that exposure to bisphenol A and phthalates was linked to hyperandrogenism and altered hormone ratios. Additionally, heavy metals were found elevated in PCOS patients, correlating with metabolic disturbances.
Key findings
- Exposure to bisphenol A and phthalates was linked to hyperandrogenism and altered luteinizing hormone/follicle-stimulating hormone ratios.
- Heavy metals such as cadmium, lead, and mercury were significantly elevated in women with PCOS.
- Metabolic disturbances, including insulin resistance and obesity indices, were associated with these toxicant exposures.
Why it matters
Understanding the role of environmental toxicants in PCOS can help clinicians recognize potential contributing factors to the syndrome's complex endocrine and metabolic dysregulation, guiding more comprehensive patient management.
What to keep in mind
Heterogeneity in exposure assessment, biological matrices, and PCOS diagnostic criteria limits causal interpretation.