Prevalence of plasma coagulation deficiencies and antiphospholipid antibodies positivity in the pediatric population of the Małopolska region: A single-center study from a pediatric hospital in Kraków.
Pediatr Hematol OncolJul 10, 2026 (epub)
Aleksandra Zima, Joanna Zdziarska, Teresa Iwaniec et al.
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In 30 seconds
This single-center study assessed the prevalence of plasma coagulation disorders and antiphospholipid antibodies in 120 children aged 3-10 years in the Małopolska region. The study found that 28.33% of participants had decreased activity of one or more coagulation factors, with a higher prevalence of 33.33% in the study group compared to 23.33% in controls.
Key findings
- 28.33% of children exhibited decreased activity of one or more coagulation factors.
- 33.33% prevalence of coagulation disorders was found in the study group.
- A positive family history of bleeding increased the likelihood of a coagulation disorder (OR 5.25, p = 0.002).
- Routine screening assays showed low sensitivity for detecting mild hemostatic abnormalities.
Why it matters
Understanding the prevalence of coagulation disorders in children is essential for timely diagnosis and management. This study underscores the importance of thorough family histories and the limitations of standard screening tests in identifying these conditions.