Fatal amlodypine overdose: forensic and clinical features - a systematic review.
Leg Med (Tokyo)Jul 8, 2026 (epub)
Agnieszka Mariowska, Filip Nowicki, Paulina Horwat et al.
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In 30 seconds
This systematic review analyzed 17 cases of fatal amlodipine overdose, primarily involving middle-aged men, with most incidents classified as suicides. The average age of the individuals was 43.8 years. The study highlights the challenges in post-mortem diagnosis and the common autopsy findings of lung congestion and edema.
Key findings
- The average age of individuals in the study was 43.8 years.
- Most cases of overdose were classified as suicides, occurring primarily at home.
- The most common autopsy finding was passive congestion and edema in the lungs.
- Toxicological tests most frequently analyzed blood for amlodipine content.
Why it matters
Understanding the clinical and forensic features of fatal amlodipine overdoses is crucial for improving post-mortem diagnostic accuracy and addressing the public health implications of this common medication.