Prepartum acquired hemophilia A: managing a double challenge for mother and child.
Audrey Hochart, Bénédicte Wibaut, Louis Terriou et al.
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Case in brief
This report discusses four cases of antenatally diagnosed acquired hemophilia A, a rare condition during pregnancy that poses risks of hemorrhage for both mother and child. All patients were treated with corticosteroids and tailored hemostatic strategies. Transplacental transfer of FVIII inhibitors occurred in three neonates, resulting in transient low FVIII levels, but only one experienced mild bleeding. All infants achieved spontaneous remission shortly after birth.
Diagnostic / clinical pearl
Prepartum diagnosis of acquired hemophilia A is crucial for optimizing maternal management and preventing severe neonatal bleeding complications.
Why it matters
This case series underscores the importance of individualized peripartum strategies and structured neonatal surveillance in managing acquired hemophilia A during pregnancy.