Symptomatic conversion in a case of sporadic frontotemporal dementia: Longitudinal neuroimaging of the presymptomatic stage.
Willem Lucas Hartog, Diederick M de Leeuw, Sterre C M de Boer et al.
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Case in brief
A 61-year-old male with sporadic behavioral variant frontotemporal dementia (bvFTD) presented with a confirmed diagnosis following a resection of meningioma 20 years prior. Longitudinal MRI scans revealed structural changes in the frontoinsular and anterior temporal cortices occurring 5-9 years before symptom onset. The case highlights the potential for early neuroimaging to identify changes in sporadic bvFTD.
Diagnostic / clinical pearl
This case illustrates that structural brain changes in sporadic bvFTD can precede clinical symptoms by several years, emphasizing the importance of longitudinal neuroimaging in understanding disease progression.
Why it matters
The findings suggest that repeated follow-up imaging in non-genetic bvFTD may enhance understanding of early neurodegenerative changes, potentially aiding in earlier diagnosis and intervention strategies.