Efficacy of Multiple Micronutrient Supplements during Pregnancy on Zinc Status among Pregnant Women in Ghana: A Randomized Trial.
J NutrJul 12, 2026 (epub)
K Ryan Wessells, Seth Adu-Afarwuah, Charles D Arnold et al.
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In 30 seconds
This randomized controlled trial evaluated the effects of multiple micronutrient supplements (MMS) versus iron and folic acid (IFA) on zinc status in 250 pregnant women in Ghana. At 36 weeks of gestation, plasma zinc levels did not significantly differ between the MMS and IFA groups, with mean concentrations of 52.9 μg/dL and 52.2 μg/dL, respectively (P = 0.25).
Key findings
- At baseline, 16.5% of women were zinc deficient.
- At 36 weeks, the prevalence of zinc deficiency was 43.0% in the IFA group and 38.4% in the MMS group (P = 0.24).
- Mean plasma zinc concentration decreased from baseline to 36 weeks in both groups.
Why it matters
Zinc deficiency during pregnancy is linked to adverse maternal and infant outcomes. Understanding the efficacy of supplementation strategies is crucial for improving maternal health in vulnerable populations.