Postprandial Vitamin E Plasma Enrichment and Second Meal Effect in Women with and without Metabolic Dysfunction-Associated Steatotic Liver Disease.
Pierre-Christian Violet, Thom Greene, Stephanie Teng et al.
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In 30 seconds
This randomized controlled trial examined postprandial vitamin E absorption in healthy women and those with obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). Results indicated that a lower fat meal sequence (0% fat) significantly enhanced the second meal effect (SME) and postprandial vitamin E enrichment compared to a higher fat sequence (40% fat). The SME was 55% higher in the 0% fat group (15.8% ± 1.1% vs 10.2% ± 1.1%, P < 0.009).
Key findings
- The second meal effect was 55% higher in the 0% fat group compared to the 40% fat group (15.8% ± 1.1% vs 10.2% ± 1.1%, P < 0.009).
- Obese women with MASLD had a 31% lower SME compared to controls (0.87% ± 0.1% vs 1.26% ± 0.1%, P = 0.047).
- Postprandial vitamin E enrichment was significantly greater in the 0% fat group at 12 and 24 hours (P < 0.04).
Why it matters
Understanding the impact of dietary fat sequences on vitamin E absorption can inform nutritional strategies for improving metabolic health, particularly in populations with obesity and liver dysfunction.