Uptake of breast cancer risk-management strategies among unaffected BRCA 1/2 carriers: a systematic review of international evidence.
Lea Godino, Giovanni Innella, Chiara Di Palo et al.
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In 30 seconds
This systematic review examined the uptake of breast cancer risk management strategies among unaffected BRCA1/2 carriers, analyzing 32 studies published from 2002 to 2025. The findings revealed that uptake of risk-reducing mastectomy (RRM) varied significantly, ranging from approximately 0% to 81.6%, with higher rates in North America. Intensive surveillance was more commonly adopted, with adherence exceeding 80-90%.
Key findings
- Uptake of risk-reducing mastectomy ranged from approximately 0% to 81.6%.
- Intensive surveillance adherence often exceeded 80-90% among women not undergoing surgery.
- The proportion of women not adopting any preventive strategy ranged from 2.8% to 9.7%.
Why it matters
Understanding the variability in uptake of risk management strategies among BRCA1/2 carriers is crucial for improving patient counseling and access to preventive measures. This knowledge can inform healthcare providers about the effectiveness of different strategies across diverse populations.