Influence of Oliceridine on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients Stratified Using Apfel Score After General Anesthesia: A Prospective, Randomized Controlled Clinical Study.
J Invest SurgJul 14, 2026 (epub)
Xinyang Heng, Aina Xu, Yajing Xiong et al.
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In 30 seconds
This randomized controlled trial evaluated the effects of oliceridine versus fentanyl on postoperative nausea and vomiting (PONV) in 279 high-risk patients undergoing general anesthesia. Oliceridine significantly reduced nausea (26.4% vs 12.9%, p = 0.005) and vomiting (24.3% vs 6.5%, p < 0.001) rates, suggesting its potential as an effective alternative for managing PONV.
Key findings
- Oliceridine reduced nausea incidence to 12.9% compared to 26.4% with fentanyl (p = 0.005).
- The vomiting rate was significantly lower with oliceridine at 6.5% versus 24.3% for fentanyl (p < 0.001).
- Postoperative nausea VAS score was lower in the oliceridine group (1.40 ± 1.31 vs 2.01 ± 1.79, p = 0.013).
- Rescue antiemetic treatment was needed in 7.2% of oliceridine patients compared to 17.1% in the fentanyl group (p = 0.011).
Why it matters
Postoperative nausea and vomiting are common complications that can hinder recovery and patient satisfaction. This study suggests that oliceridine may offer a more effective management option for PONV in high-risk surgical patients, potentially improving postoperative outcomes.