Intensified multifactorial intervention leads to long-term benefit on kidney outcomes in advanced diabetic kidney disease: A 10-year follow-up of the DNETT-Japan trial.
J Diabetes InvestigJul 14, 2026 (epub)
Kenichi Shikata, Satoshi Miyamoto, Masakazu Haneda et al.
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In 30 seconds
This randomized controlled trial evaluated the long-term effects of an intensive multifactorial treatment on kidney outcomes in 164 patients with advanced diabetic kidney disease over a 10-year period. The study found that the risk of a composite primary outcome was significantly lower in the intensive treatment group compared to the conventional group, with a hazard ratio of 0.62.
Key findings
- The intensive treatment group had a lower risk of the primary outcome with a hazard ratio of 0.62.
- Increases in systolic blood pressure (per 10 mmHg) were associated with a higher risk of the primary outcome (hazard ratio, 1.43).
- Increases in serum low-density lipoprotein cholesterol (per 10 mg/dL) also correlated with a higher risk of the primary outcome (hazard ratio, 1.23).
Why it matters
The findings underscore the importance of sustained, intensive management of multiple risk factors in patients with advanced diabetic kidney disease, which may lead to improved long-term kidney outcomes.